The COVID-19 pandemic hasn’t been the only thing reshaping medicine.

Leaders at Health2047—the Silicon Valley-based subsidiary of the AMA created to overcome systemic dysfunction in the U.S. health care system—have been busy transforming medicine in meaningful ways in 2021 to help ensure that patients and physicians will have a health care system that meets their needs by midcentury. Already this year, Health2047 has spun out three companies poised to reshape health care.

“Our business momentum continues to accelerate as we and our strategic partners develop and commercialize system-level solutions in chronic care, data utility, radical productivity, and health care value,” said Health2047 CEO Lawrence Cohen.

“We continue to find, form and scale the companies needed to transform U.S. health care at the system level, and expect to announce more spinouts in the second half of 2021,” Cohen added.